What is Corrositex?

Corrositex Instruction Manual-(PDF)
This manual is password Protected. Please contact InVitro International
in Placentia, CA. for a password.

Corrositex is an invitro test that determines chemical corrosivity and permits assignment of Packing Group classification for Class 8 corrosives. This test replaces the rabbit test of dermal corrosivity by providing a reliable means of mimicking this test. The proprietary core technology of the Corrositex test is based upon a biomembrane and chemical detection system, which becomes colored when exposed to potentially corrosive substances.

How the Test Works

The Corrositex testing system consists of a glass vial filled with a chemical detection fluid capped by a proprietary bio-barrier membrane, which is designed to mimic the effect of corrosives on living skin.
As soon as the corrosive sample destroys this bio-barrier, the fluid below changes color or texture. Users simply record the time it takes for the sample to break through the membrane. Then, depending on their needs, they can assign the proper U.N. Packing Group classification for U.S. DOT or EPA compliance, or use the data as a ranking tool or to substantiate marketing claims.

Why Use Corrositex?

Because it will save you time and money.

  • Time Savings: Unlike animal testing that can take 2 to 4 weeks, Corrositex testing can provide a Packing Group determination in as little as 3 minutes and no longer than 4 hours.
  • Cost Savings: In a recent evaluation, one customer saved up to $50,000 annually, in shipping costs, for a single compound when using the Corrositex test to define the Packing Group instead of relying on pH. In addition to the reduction in shipping charges, additional cost savings are found in the areas of workplace safety and MSDS development.

Regulatory Acceptance. Following is a list of agencies that accept Corrositex. This list continues to grow as regulatory bodies look for more accurate, cost-effective and humane testing methods. Copies provided upon request.
Department of Transportation - DOT-E 10904
Original exemption granted April 28, 1993
A special permit is no longer necessary. The provisions of DOT-SP 10904 were incorporated into the Hazardous Materials Regulations under Docket No. HM-215K in a final rule published in the Federal Register on January 19, 2011 (76 FR 3308). The authority is now contained in 173.137. A copy of HM-215K can also be found at:

Consumer Product Safety Commission (CPSC)
Formal Acceptance, NIEHS press release dated 3/21/00
European Centre for the Validation of Alternative Methods (ECVAM)
Approval July 19, 2006
EPA Federal Register / Vol. 60, No. 142 Dermal Corrosion
Method 1120       June 13, 1997
Formal Acceptance, NIEHS press release dated 3/21/00
Food & Drug Administration (FDA)
Formal Acceptance, NIEHS press release dated 3/21/00
International Air Transportation Association (IATA)
Letter of acceptance dated December 17, 1993
National Institute of Environmental Health Sciences (NIEHS)
Endorsement dated 6/22/99
Occupational Safety and Health Administration (OSHA)
Letter of Interpretation dated March 3, 1994
Formal Acceptance, NIEHS press release dated 3/21/00
Transport Canada - Permit For Equivalent Level of Safety SU 4483
Original approval 8/14/96
Additional renewal 9/18/98
Additional renewal 1/15/01
Full Draize Replacement Acceptance 3/5/02

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Corrositex Instruction Manual

This manual is password Protected. Please contact InVitro International for a password.